Functional Genomics of Cancer and Rare Diseases
Room Nmb. 2031
Hongling Yuan, M.D. (Specialist)
Burcu Akman (Ph.D. student)
Esra Baytak (MSc student)
Deniz Kurşun (MSc student)
Our current research mainly focuses on the identification and characterization of novel mutations and epigenetic alterations of tumor suppressor genes or oncogenes in cancers and aberrant genes in rare diseases. Our interest mainly resides in hematological malignancies with a particular focus on common lymphomas (e.g. follicular lymphoma) and leukemias (e.g. acute myeloid leukemia) which are neoplastic diseases having a high degree of genetic heterogeneity.
We frequently use next generation sequencing (NGS) based technologies to generate a candidate list of aberrant genes using panels of lymphoma patient samples. We then validate mutations by applying Sanger sequencing that is identified through whole exome sequencing (WES) and/or RNA-sequencing. Moreover, our studies focus on genome-wide methylation changes in gene promoter regions of cancer samples. Altogether, we characterize these aberrations using a combination of genetic, epigenetic and molecular biology assays. In general, our studies follow a wholistic approach which involves the cooperation of a variety interrelated biomedical disciplines such as pathology, functional genomics, and computational bio-informatics. Our eventual goal is to identify and characterize genetic and epigenetic abnormalities in every cancer patient to translate the discoveries as personalized medicine.
Küçük lab is currently seeking highly-motivated graduate students. If interested, please contact Dr. Küçük by email: email@example.com
|Can Küçük’s CV
|04/15 – present||Assistant Professor of Medical Biology, Izmir International Biomedicine and Genome Institute, Izmir, Turkey.|
|11/14 – 03/15||Tübitak 2232 grantee, Dokuz Eylul University Izmir Biomedicine and Genome Center, Izmir, Turkey.|
|10/13 – 10/14||Postdoctoral Research Fellow, Department of Pathology, City of Hope Medical Center, Duarte, CA, USA.|
|10/12 – 09/13||Postdoctoral Research Associate, Department of Pathology and Microbiology, University of Nebraska Medical Center (UNMC), Omaha, NE, USA.|
|12/06 – 10/12||Ph.D. in Cancer Biology and Oncology, Cancer Research Graduate Program (CRGP), University of Nebraska Medical Center (UNMC), Omaha, NE, USA.|
|09/05 – 12/06||Graduate Research Assistant* in Development, Cell and Neurobiology, Lousiana State University Health Sciences Center (LSUHSC), New Orleans, LA, USA.|
|09/01 – 07/05||B.Sc. in Molecular Biology and Genetics, Middle East Technical University (METU), Ankara, Turkey.|
|*: Transferred to a new Ph.D. program due to Hurricane Kathrina.|
|AWARDS AND RECOGNITION
• Science Academy – Young Scientist Award (BAGEP),Turkey, 2015.
• TÜBİTAK – BİDEB 2232 Reintegration Grant, Turkey, 2014.
• American Society of Hematology (ASH) – Abstract Achievement Award, USA, 2013.
• UNMC – Graduate Studies Assistantship (Competetive renewal at 2010), USA, 2009.
• TÜBİTAK – Basic Sciences B Scholarship, Turkey, 2002.
Full list and citations: Google Scholar: Can Kucuk